Metrological characterisation of reconstruction techniques in silico
The aim of this work package is to metrologically characterise the quantitative imaging methods for EPT and MRF developed and implemented in WP1, in a completely controlled environment constituted by virtual experiments conducted on realistic in silico models. Moreover, the use of the imaged quantities as physical biomarkers for the presence and/or stage of both localised and diffused pathologies will be investigated.
Virtual experiments will be carried out by solving Maxwell’s and Bloch’s equations sequentially, providing realistic data in completely controlled conditions for the metrological characterisation of EPT and MRF procedures, which, in addition, will allow verifying the feasibility of an MRF-based B1-mapping to be used as an input for EPT. The characterisation will be extended to the detection of anomalies in altered virtual human models imaged with EPT and MRF. Besides traditional statistical approaches, state of the art machine learning techniques will be adopted and tested.